Epigenetics: Genetic Material – Subject to Change

Why does the queen bee look different from her workers even though she shares the same genome? Why do liver cells and kidney cells have different functions despite sharing the same DNA sequence? These differences are the result of epigenetic mechanisms. They control our genome by turning genes on or off. Many studies show that even environmental influences and lifestyle precipitate epigenetic adaptations. Among them exercise and nutrition, but also differences in social status. These three examples show we are not at the mercy of the negative external influences on our genes; instead, much is in our own hands.

Exercise activates epigenetic activity
The fact that exercise plays a key role in health and longevity is known around the world. The exact influence that movement exerts on our cells is the topic of research of many groups. For example, in the spring of 2019, a team led by biologist Birgitte Regenberg at the University of Copenhagen published a study comparing the muscle cells of athletic men to those of less active men between 60 and 65 years of age. The result: the genetic material of the athletic subjects differed from that of the less athletic subjects in more than 700 locations. Accordingly, genes which control muscle development or energy production are “read” more frequently in those people who are more active.
As far back as the 1990s, the large-scale HERITAGE Family Study set out to discover the exact tissues that were affected by these genetic changes. According to the study, cycling exerted positive effects on the PCG-1α gene – the key molecule in energy metabolism. In April 2023, a study conducted by Ahmad Aziz and his team at the German Center for Neurodegenerative Diseases (DZNE) found that regular exercise slows epigenetic aging. Movement thus counteracts the age-related decline of the immune system, and it lowers the risk of cardiovascular illness.

The nutrition of a mother and father determines their children’s epigenome – even prior to conception
It’s been known for a long time that the nutritional status of a woman during pregnancy and lactation influences the metabolism of the child later in life. Further to this fact, the nutrition of both parents prior to conception can affect the metabolic health of the child – via epigenetic changes that can even be passed down. One example: as a result of being overweight, important switches inside the genome can be altered, which, in turn, will increase the risk of type 2 diabetes and obesity.
According to studies conducted by the German Center for Diabetes Research (DZD) at the Helmholtz Center Munich and the Technical University of Munich, these epigenetic mechanisms can be passed down to unborn children via the epigenetic code in sperm and egg cells. As a result, this will determine whether, and to which extent, these children will suffer from illness during their lifetime. The good news: children are not entirely dependent on the genes of their parents, but they can benefit from their own healthy life choices. According to the researchers, epigenetic information can be reversed within a specific time window. If a child of parents with metabolic illness receives healthy nutrition and sufficient exercise, future generations will reap the reward.

Social inequality is reflected in the genes of children
The research groupMPRG Biosocial I Biology, Social Disparities, and Development from the Max Planck Institute for Human Development studied the influence of social inequality on genes. The team, headed by Laurel Raffington, analyzed data from more than 3,000 American children between the ages of eight and 18. One result: the epigenetic profiles of children from socially and economically disadvantaged families and neighborhoods were “worse” than those of young people growing up in privileged circumstances. They show similarities with those profiles which in previous studies had been connected with a less favorable health status in adults. Among them, an elevated risk of obesity, lower cognitive abilities and accelerated aging. With her research, the developmental psychologist intends to provide facts that will facilitate the necessary changes – for example, with respect to social policy. After all: evidence points to the fact that epigenetic profiles may be influenced through a healthy lifestyle and early childhood education.